So we have established the weakness of kindred, but what does one use to bring final Death to immortals?
Fire arms?, Blades? Holy Relics???
Shotgun: A gun is more of a nuisance more than a real threat, but a shotgun blast to the torso is a very different thing entirely.
Fire: Burn baby BURN!!!! Fire is one of the weaknesses that where bestowed to Cain and his childer, every kindred has a weakness against the Flame, so it is naturaly part of a Demon Hunters arsenal.
Blades: Knives, Machetes, Swords, Razors All are good, any kind of weapon that can cleave through meat is good arsenal against Kindred, although Vampires have no living organs regenerating damage by a Blade that was wrenched from its body is a grueling task, also Decapitation is pretty good to giving final death. But there is a Draw back if you are found patrolling the streets with a Katana Blade.
Wooden Stake: The mighty cliche of a stake through the Heart. Indeed it does work but partly. A stake through the heart only Paralyses a vampire rending him helpless and is easy game for any Hunter.
Holy Relics: A cross, The crescent, a Swastika, Any emblem that you consider Holy that could repel evil spirits may well serve you, for a Holy relic is nothing without the Faith of the person to back it up, The fire of Faith burns more brightly if you actually believe in it.
Sunlight: The best weapon for vampire hunters is The Sun, it is at that time that kindred sleep, but if one finds a kindred´s haven in the morning hours, well its time to kiss daylight.